Animal safety studies: well tolerated at up to 40x normal daily oral dose.
In animal safety studies, SIMPLICEF™ (cefpodoxime proxetil) was well tolerated at up to 40x the normal daily oral dose for 13 weeks in adult dogs and 28 days in puppies (18-23 days of age).
Safety has been demonstrated in dogs for up to six months of daily therapy.
1
Contraindications and warnings are similar to other cephalosporins.
1
118 dogs of various breeds and all ages were included in this field study safety analysis.
SIMPLICEF™ (cefpodoxime proxetil) should not be used in dogs that are hypersensitive to penicillin
or cephalosporin. Safety in pregnant and lactating animals or breeding male dogs has not
been established.
1
Proprietary data on file.
SIMPLICEF is a trademark of Pharmacia & Upjohn. ©2004 Pfizer Inc. All rights reserved
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Copyright © 2008 Pfizer Inc. All rights reserved.
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